What is DHEA?
DHEA (Dehydroepiandrosterone) is the most abundant steroid hormone in the body, produced primarily by the adrenal glands. It is a precursor to both testosterone and estrogen and has independent biological effects. DHEA levels peak in the mid-20s and decline by ~80% by age 70 — one of the most dramatic age-related hormonal declines. Restoring DHEA to youthful levels is a cornerstone of anti-aging hormone therapy.
Mechanism of Action
DHEA acts as a precursor to sex hormones (testosterone, estrogen) and has direct effects through DHEA receptors. It activates PPAR-α (fat metabolism), has anti-glucocorticoid effects (opposing cortisol), activates NMDA receptors in the brain (cognitive effects), and has anti-inflammatory properties.
DHEA Dosing Protocol
25–100 mg/day oral (typical anti-aging dose). Women: 10–25 mg/day (lower due to androgenic effects). Take in the morning (mimics natural adrenal rhythm). Monitor DHEA-S, testosterone, and estradiol after 4–6 weeks.
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DHEA Benefits
Side Effect Profile
Acne, oily skin, hair loss (androgenic effects, especially in women), potential for elevated estrogen (monitor), mood changes. Women should use lower doses (10–25 mg) to avoid virilization.
DHEA Stacking Guide
DHEA works synergistically with these compounds. Click any to learn more, or ask PepBot to build you a complete stack.
Research & Citations
Frequently Asked Questions about DHEA
What DHEA-S level should I target?
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