What is Fisetin?
Fisetin is a naturally occurring flavonoid found in strawberries, apples, and other fruits. It is the most potent natural senolytic compound identified — it selectively kills senescent cells (zombie cells) that accumulate with age and drive inflammation and tissue dysfunction. It also has neuroprotective, anti-inflammatory, and anti-cancer properties.
Mechanism of Action
Fisetin is a senolytic that selectively induces apoptosis in senescent cells by inhibiting anti-apoptotic pathways (BCL-2, BCL-XL) that senescent cells rely on for survival. It also activates SIRT1, inhibits mTOR, reduces inflammatory cytokines (IL-6, TNF-α), and has direct antioxidant effects.
Fisetin Dosing Protocol
Senolytic protocol: 20 mg/kg/day for 2 consecutive days, repeated every 1–3 months (the 'Fisetin pulse' protocol). For a 75 kg person: ~1,500 mg/day for 2 days. Daily maintenance: 100–500 mg/day. Take with fat for better absorption.
Want a personalized protocol? Tell PepBot your goals, health status, and experience level for a custom Fisetin protocol.
Fisetin Benefits
Side Effect Profile
Generally well-tolerated. Mild GI discomfort at high senolytic doses. Theoretical: removing too many senescent cells at once could cause immune activation (start with lower doses).
Fisetin Stacking Guide
Fisetin works synergistically with these compounds. Click any to learn more, or ask PepBot to build you a complete stack.
Research & Citations
Frequently Asked Questions about Fisetin
What is the Fisetin senolytic protocol?
Still have questions about Fisetin?
PepBot has encyclopedic knowledge of Fisetin — dosing, stacking, interactions, latest research, and personalized protocols. Ask anything.