What is Ipamorelin?
Ipamorelin is a selective growth hormone secretagogue and ghrelin receptor agonist. It is considered the 'cleanest' GHRP because it stimulates GH release with virtually no effect on cortisol, prolactin, or ACTH — making it ideal for long-term use. It is almost always stacked with CJC-1295 for synergistic GH pulses.
Mechanism of Action
Ipamorelin binds to the ghrelin receptor (GHSR-1a) in the pituitary gland, triggering a strong, selective pulse of growth hormone release. Unlike GHRP-6 and GHRP-2, it does not significantly stimulate cortisol or prolactin, making it far more suitable for frequent dosing.
Ipamorelin Dosing Protocol
200–300 mcg per injection, 2–3 times daily (ideally before bed, upon waking, and pre-workout). Most commonly stacked with CJC-1295 (without DAC) at the same dose and timing. Cycle: 12–16 weeks on, 4–8 weeks off.
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Ipamorelin Benefits
Side Effect Profile
Mild water retention initially. Occasional mild hunger (much less than GHRP-6). Rare: tingling or numbness. Extremely well-tolerated for long-term use.
Ipamorelin Stacking Guide
Ipamorelin works synergistically with these compounds. Click any to learn more, or ask PepBot to build you a complete stack.
Research & Citations
Frequently Asked Questions about Ipamorelin
Should I take Ipamorelin with or without food?
Ipamorelin vs GHRP-6 — which is better?
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