What is LGD-4033?
LGD-4033 (Ligandrol) is a selective androgen receptor modulator developed by Ligand Pharmaceuticals. It is the most anabolic SARM available and has completed Phase I and II clinical trials. It produces significant lean muscle mass gains comparable to low-dose testosterone but with far fewer androgenic side effects.
Mechanism of Action
LGD-4033 binds to androgen receptors with very high affinity and selectivity for muscle and bone tissue. It activates anabolic signaling pathways (mTOR, protein synthesis, nitrogen retention) in muscle while showing minimal activity in the prostate and other androgenic tissues.
LGD-4033 Dosing Protocol
5–10 mg/day oral for muscle building. 2–5 mg/day for body recomposition or cutting. Cycle: 8–12 weeks. PCT is strongly recommended — LGD-4033 causes significant testosterone suppression.
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LGD-4033 Benefits
Side Effect Profile
Significant testosterone suppression (requires PCT), mild liver enzyme elevation, potential lipid changes (reduced HDL). Stronger side effect profile than Ostarine — bloodwork is essential.
LGD-4033 Stacking Guide
LGD-4033 works synergistically with these compounds. Click any to learn more, or ask PepBot to build you a complete stack.
Research & Citations
Frequently Asked Questions about LGD-4033
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