What is Semaglutide?
Semaglutide is a GLP-1 (glucagon-like peptide-1) receptor agonist that mimics the gut hormone GLP-1 to suppress appetite, slow gastric emptying, and improve insulin sensitivity. Originally developed for type 2 diabetes (Ozempic), it became a blockbuster weight loss drug (Wegovy) after clinical trials showed 15% average body weight reduction.
Mechanism of Action
Semaglutide binds to GLP-1 receptors in the brain (hypothalamus), gut, and pancreas. It suppresses appetite by reducing ghrelin and increasing satiety signals, slows gastric emptying to reduce caloric intake, stimulates insulin secretion in a glucose-dependent manner, and reduces glucagon secretion. It also has direct cardiovascular protective effects.
Semaglutide Dosing Protocol
Start at 0.25 mg/week subcutaneous for 4 weeks → 0.5 mg/week for 4 weeks → 1 mg/week → titrate to 2.4 mg/week (max for weight loss). For diabetes: 0.5–1 mg/week. Inject once weekly, same day each week.
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Semaglutide Benefits
Side Effect Profile
Nausea (most common, especially during titration), vomiting, diarrhea, constipation. Rare: pancreatitis, gallbladder issues. Titrate slowly to minimize GI side effects. Not for use with personal/family history of medullary thyroid carcinoma.
Semaglutide Stacking Guide
Semaglutide works synergistically with these compounds. Click any to learn more, or ask PepBot to build you a complete stack.
Research & Citations
Frequently Asked Questions about Semaglutide
How much weight can I lose on Semaglutide?
What is the difference between Semaglutide and Tirzepatide?
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