What is TB-500?
TB-500 is a synthetic version of the naturally occurring peptide Thymosin Beta-4, found in virtually all human and animal cells. It is one of the most potent systemic healing peptides available, with a unique ability to travel through the bloodstream to sites of injury and promote repair from within.
Mechanism of Action
TB-500 works by upregulating actin — the protein that builds cell structure and enables cell migration. It promotes angiogenesis (new blood vessel formation), reduces inflammation via NF-κB pathway modulation, activates satellite cells for muscle repair, and promotes stem cell differentiation. Its small molecular size allows it to circulate systemically.
TB-500 Dosing Protocol
Loading phase: 2–2.5 mg twice per week for 4–6 weeks. Maintenance: 2–2.5 mg once per week. Total cycle: 6–12 weeks. For acute injuries, some researchers use 5 mg/week for the first 2 weeks.
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TB-500 Benefits
Side Effect Profile
Generally well-tolerated. Occasional reports of head rush or fatigue immediately after injection. Theoretical concern about promoting growth in existing tumors (not demonstrated in healthy subjects).
TB-500 Stacking Guide
TB-500 works synergistically with these compounds. Click any to learn more, or ask PepBot to build you a complete stack.
Research & Citations
Frequently Asked Questions about TB-500
What is the difference between TB-500 and BPC-157?
How long does TB-500 take to work?
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