What is Urolithin A?
Urolithin A is a metabolite produced by gut bacteria from ellagitannins found in pomegranates, walnuts, and berries. It is the most potent known activator of mitophagy — the cellular process of clearing damaged mitochondria and replacing them with new, healthy ones. It has completed Phase I and II clinical trials and is commercially available as Mitopure.
Mechanism of Action
Urolithin A activates mitophagy by inhibiting mTOR and activating PINK1/Parkin pathways, which tag damaged mitochondria for degradation. This clears dysfunctional mitochondria and stimulates mitochondrial biogenesis, resulting in a net improvement in mitochondrial quality and function.
Urolithin A Dosing Protocol
500–1,000 mg/day oral (Mitopure). Clinical trials used 500 mg and 1,000 mg/day. Take with food. Effects build over weeks to months — not an acute supplement.
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Urolithin A Benefits
Side Effect Profile
Extremely well-tolerated. Mild GI discomfort at high doses. No significant adverse effects in clinical trials.
Urolithin A Stacking Guide
Urolithin A works synergistically with these compounds. Click any to learn more, or ask PepBot to build you a complete stack.
Research & Citations
Frequently Asked Questions about Urolithin A
Is Urolithin A the same as Mitopure?
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