What is VIP?
VIP (Vasoactive Intestinal Peptide) is a 28-amino acid neuropeptide found throughout the nervous system and immune system. It is one of the most potent anti-inflammatory neuropeptides known and has gained significant attention in the CIRS (Chronic Inflammatory Response Syndrome) community, particularly for biotoxin illness (mold, Lyme disease). Dr. Ritchie Shoemaker has used VIP as the final step in his CIRS treatment protocol.
Mechanism of Action
VIP binds to VPAC1 and VPAC2 receptors, activating cAMP signaling that suppresses pro-inflammatory cytokines (TNF-α, IL-6, IL-12), activates regulatory T-cells, promotes Th2 immune responses, has vasodilatory effects, and regulates circadian rhythms. It is a master regulator of the neuroimmune axis.
VIP Dosing Protocol
50 mcg intranasal 4 times daily (Shoemaker CIRS protocol). Some researchers use 50–100 mcg 2–4 times daily. Must be used only after other CIRS treatments are completed (otherwise can worsen symptoms).
Want a personalized protocol? Tell PepBot your goals, health status, and experience level for a custom VIP protocol.
VIP Benefits
Side Effect Profile
Generally well-tolerated intranasally. Can worsen symptoms if used before completing CIRS protocol steps. Occasional: nasal irritation, headache.
VIP Stacking Guide
VIP works synergistically with these compounds. Click any to learn more, or ask PepBot to build you a complete stack.
Research & Citations
Frequently Asked Questions about VIP
Can VIP help with mold illness/CIRS?
Still have questions about VIP?
PepBot has encyclopedic knowledge of VIP — dosing, stacking, interactions, latest research, and personalized protocols. Ask anything.