The anti-aging peptide field has exploded with the discovery of compounds that directly address the hallmarks of aging: telomere shortening (Epithalon), mitochondrial dysfunction (SS-31, MOTS-c), cellular senescence (Klotho), and systemic inflammation (Thymalin, Vilon). Here's the evidence-based ranking.
The most extensively studied anti-aging peptide. Activates telomerase, normalizes melatonin, 25% lifespan extension in animal models. 40+ years of Khavinson research.
The 'longevity protein' — single injection improved cognitive function for months in primate studies. Regulates FGF23, reduces inflammation, protects kidneys and cardiovascular system.
Activates 31 anti-aging genes. Resets gene expression toward a younger profile. Promotes collagen, reduces inflammation, protects DNA.
Khavinson's thymus bioregulator. Restores immune function in aging. Clinical trials showed 2.5x reduction in mortality over 6 years in elderly patients.
Mitochondrial-derived peptide that improves metabolic health, insulin sensitivity, and physical performance. Declines with age — supplementation reverses metabolic aging markers.
Foundation protocol: Epithalon (10 mg/day × 10 days, twice yearly) + GHK-Cu (1 mg/day SubQ ongoing). Advanced: Add Thymalin (10 mg/day × 10 days, twice yearly, alternating with Epithalon) + MOTS-c (5 mg/week). Cutting edge: Add Klotho (emerging protocol) + SS-31 (10 mg/week) for mitochondrial protection.
[1] Khavinson VKh et al. (2003). Epithalon peptide induces telomerase activity. Bull Exp Biol Med. PMID: 12937682
[2] Kuro-o M et al. (1997). Mutation of the mouse klotho gene leads to a syndrome resembling ageing. Nature. PMID: 9363890
[3] Pickart L & Margolina A (2018). Regenerative and Protective Actions of the GHK-Cu Peptide. Int J Mol Sci. PMID: 30200541
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